John Maraganore joined Alnylam in 2002, bringing over 25 years of experience in Research and Development, and business roles with biotechnology companies. Prior to Alnylam he served as an officer and a member of the management team for Millennium Pharmaceuticals, Inc. As Senior Vice President, Strategic Product Development for Millennium, Dr. Maraganore was responsible for the company's product franchises in Oncology, Cardiovascular, Inflammation, and Metabolic Diseases. He was previously Vice President, Strategic Planning and M&A and prior to that he was General Manager of Millennium BioTherapeutics, Inc., a former subsidiary of Millennium. Before Millennium, he served as Director of Molecular Biology and Director of Market and Business Development at Biogen, Inc. (now Biogen Idec, Inc.). At Biogen, John invented and led the discovery and development of Angiomax™ (bivalirudin for injection, formerly Hirulog™) currently marketed by The Medicines Company. Prior to Biogen, he was a scientist at ZymoGenetics, Inc., and The Upjohn Company. John received his M.S. and Ph.D. in biochemistry and molecular biology at the University of Chicago. Dr. Maraganore is a Director for Agios Pharmaceuticals, Regulus Therapeutics, Tempero Pharmaceuticals, and bluebird bio. In addition, he is an advisor to Third Rock Ventures. John is also a member of the Immunology Advisory Council of Harvard Medical School and a member of the Biotechnology Industry Organization Board.
Barry Greene joined Alnylam in 2003, and brings over 20 years of experience in healthcare, pharmaceutical, and biotechnology industries. Prior to Alnylam, he was General Manager of Oncology at Millennium Pharmaceuticals, Inc., where he led the company's global strategy and execution for its oncology business including strategic business direction and execution, culminating in the successful approval and launch of VELCADE™(bortezomib) in mid 2003. Prior to joining Millennium in February 2001, Barry served as Executive Vice President and Chief Business Officer for Mediconsult.com. Prior to Mediconsult.com, his past experiences include Vice President of Marketing and Customer Services for AstraZeneca formerly AstraMerck; Vice President Strategic Integration with responsibility for the AstraZeneca North American post merger integration; and Partner, Andersen Consulting responsible for the pharmaceutical/biotechnology marketing and sales practice. Barry received his B.S. in Industrial Engineering from University of Pittsburgh and serves as Senior Scholar at Duke University, Fuqua School of Business. Barry also serves on the Board of Acorda Therapeutics, Inc.
Dr. Vaishnaw joined Alnylam in 2006, coming from Biogen, Inc. (now Biogen Idec Inc.), where he was most recently Senior Director, Translational Medicine. In his seven years at Biogen he was involved in many aspects of clinical research and business development, and led the effort for the approval of alefacept (Amevive™) for psoriasis. Akshay received his M.D. from the University of Wales College of Medicine, U.K., with Distinctions in Pathology and Medicine, and his Ph.D. from the University of London, U.K., in Molecular Immunology. He is a Member of the Royal College of Physicians, U.K. Akshay is also a member of the Scientific Advisory Board of Scholar Rock. In addition, he has published papers in leading scientific journals and authored a number of textbook chapters relating to autoimmune disease.
Karen Anderson joined Alnylam in 2014 from Biogen Idec where she served as Vice President, Human Resources for R&D and Corporate Development. Prior to Biogen Idec, Karen was the Vice President of Human Resources, Commercial for Pfizer Inc. covering both Developed Markets and Emerging Markets. Earlier in her 10-year tenure with Pfizer, Karen supported Worldwide R&D. Before joining Pfizer, she spent 6 years at Baxter, most recently as Global Human Resources Director. Her career as a human resources leader in the bio-pharma industry began in 1995, when she joined Bayer as Director of Compensation from her role as an Associate Consultant with the Hay Group. Karen received a Masters in Organizational Psychology and Development from Bowling Green State University in Ohio. She earned her Bachelor of Arts with honors in both Psychology and Labor Relations from York University in Toronto, Canada.
Dr. Bossone joined Alnylam 2010 from Shire HGT with over 15 years of experience in the biotech industry. As a Senior Patent Attorney at Shire he provided licensing, acquisition and litigation support as well as strategic input into the life cycle management of several marketed products. Steve began his career at Millennium Pharmaceuticals as a Scientist in the oncology group and then at Millennium Biotherapeutics where he headed the transcript profiling group to support drug discovery initiatives. He transitioned to the Intellectual Property field with positions of increasing authority at Millennium, ToleRx, Serono and Shire. He received his PhD in Molecular Pathology from the lab of Dr. Kenneth Marcu at SUNY Stony Brook (NY) and subsequently worked as a Research Fellow in Medicine in the lab of Dr. Vikas Sukhatme at Harvard Medical School and Beth Israel Hospital. Steve received his JD from Suffolk University School of Law.
Dr. Fitzgerald joined Alnylam in 2005 as Associate Director of Research and has served in roles of increasing responsibility and leadership since that time. His achievements at Alnylam include leadership of the company’s RNAi delivery efforts, resulting in two clinically validated modes of siRNA delivery. He has led multiple programs – including Alnylam’s PCSK9 program – from discovery through pre-clinical development, regulatory submissions, and early clinical development. Kevin was lead author and coauthor on Alnylam’s seminal papers in The Lancet and the New England Journal of Medicine, which demonstrated the effects of RNAi therapeutics in man. Prior to joining Alnylam, Kevin worked as a Senior Research Scientist and Group Leader at Bristol Myers Squibb, where he contributed to the development of multiple pharmaceutical products, in addition to managing several technology and drug development alliances. Kevin received his B.S. in Genetics from Cornell University and his Ph.D. in Molecular Biology from Princeton University. He completed his post-doctoral fellowship in oncology at Harvard Medical School.
Dr. Gandhi joined Alnylam in 2014, having previously served as Associate Vice President of Global Medical Affairs at Sanofi Oncology, where he spearheaded and executed on the global publication, medical education, and medical communication strategy. Prior to Sanofi, he worked as Regional Director of Medical Scientific Relations at Alexion Pharmaceuticals, where he managed efforts to bridge the gap between the science of eculizumab and the practice of medicine in the area of paroxysmal nocturnal hemoglobinuria (PNH). Preceding Alexion, he was at Millennium Pharmaceuticals, where he was the operational lead for the EVENT registry. Before joining the pharmaceutical industry, Pritesh held an academic appointment at Massachusetts College of Pharmacy as well as an adjunct position at The University of Massachusetts Medical School. At that time, he also practiced as Cardiovascular Pharmacotherapy Specialist at UMass Memorial Health Care. Pritesh received his B.S. in Pharmacy and his PharmD from the Massachusetts College of Pharmacy and Health Sciences. He completed a clinical residency at The University of Illinois Chicago, and is a Registered Pharmacist in the State of Illinois and the Commonwealth of Massachusetts.
Dr. Garg joins Alnylam with close to 15 years of experience in clinical drug development. Most recently, he served as Vice President, Global Clinical Research, Immunoscience at Bristol-Myers Squibb (BMS). In this role he was responsible for strategic leadership of the Immunoscience franchise and the successful development of multiple clinical assets across immune-mediated diseases in the areas of rheumatology, gastroenterology, nephrology, and transplantation. During his eight-year tenure at BMS, he was instrumental to the late-stage development and approval of Nulojix® (belatacept) for kidney transplant recipients, and for supplementary biologics license applications (BLA) for Orencia® (abatacept) around the world. Previously, Pushkal was at Millennium Pharmaceuticals, where he worked in various roles of increasing responsibility, overseeing the clinical development of multiple small molecule and biologic therapeutics for the treatment of inflammatory disorders. Pushkal received a Bachelor of Arts with high honors in Biochemistry from the University of California, Berkeley, and an M.D. from the University of California, San Francisco. He completed residency training in Internal Medicine at UCSF, was a fellow in the Robert Wood Johnson Clinical Scholars Program at Johns Hopkins University, and served on the faculty of Harvard Medical School and the Brigham & Women’s Hospital in Boston prior to joining industry.
Mr. Green joined Alnylam in 2015, having most recently worked at Synageva BioPharma, where he was Vice President of Program and Alliance Management. In that role he was responsible for the oversight, management, and leadership of the company’s lead compound being developed as an enzyme replacement therapy for an ultra-orphan genetic disease. Prior to Synageva, he worked as Senior Director, Product Development and Program Management at Infinity Pharmaceuticals, where he developed the clinical and commercial product strategy and led the operational execution for the development of a small molecule product being investigated in non-small cell lung cancer. Before working at Infinity, he spent over eight years at Genzyme Corporation, where he served in roles of increasing responsibility in program and brand management for multiple commercial oncology products. Eric received his Bachelor of Science in Chemical Engineering from the University of Michigan, a Masters in Chemical Engineering from the Massachusetts Institute of Technology (MIT), and an MBA from the MIT Sloan School of Management.
Ms. High joined Alnylam in 2007 as Senior Director, Business Planning and Program Management. Susanna joined Alnylam from Millennium Pharmaceuticals, Inc., where she most recently was Director of Corporate Strategy and prior to that Director of Business Operations. From 1996 to 2001 she held a leadership role as management consultant with Accenture in their Strategy Pharmaceutical Practice. She has more than 15 years of operations, strategic and financial management experience, locally and internationally. She holds a degree in Economics and Business from Universita' Bocconi, Milan, Italy and a Masters in Business Administration from MIT.
Laurie Bartlett Keating joined Alnylam in 2014 with more than 25 years of executive experience at high technology and biotechnology companies. Prior to joining Alnylam, Laurie served as Senior Vice President, General Counsel and Secretary of Millennium: The Takeda Oncology Company for 9 years, responsible for setting the company’s global legal, intellectual property, and corporate quality strategies and priorities. Prior to Millennium, Laurie was co-founder and the first CEO of Hydra Biosciences, Inc. Before co-founding Hydra, she served as an executive at high growth technology companies, including serving as Senior Vice President, General Counsel and Secretary of Iomega Corporation, and Sybase, Inc., a software company that grew from a few hundred to 6,000 employees during Laurie’s tenure on the management team. Based on her leadership at Sybase, she was named as one of the 45 most influential in-house lawyers in the United States under the age of 45. Upon graduating from law school, Laurie practiced law at McCutchen, Doyle, Brown and Enersen (now Bingham McCutchen) in San Francisco. She has a Doctor of Jurisprudence from the University of California, Hastings College of the Law, and a Bachelor of Arts in Economics from the University of California at Berkeley. Laurie is a member of the Board of Directors of MassBio and the immediate past chair of the BIO General Counsels Committee.
Marko Kozul, M.D. comes to Alnylam from Leerink Partners where he served as a senior biotechnology analyst for 2 years. Prior to Leerink, he served as an analyst at ThinkEquity Partners for 2 years and Jefferies & Company for 5 years. Earlier in his career, he worked as the Research Director for Variant Medical Consulting Group and as a consultant for the Medical Referral Source, Inc. Marko earned a Bachelor of Science in Cellular and Molecular Biology from the University of Michigan and an M.D. from the School of Medicine at International University of the Health Sciences. He is a member of the American Medical Association, the American Society of Clinical Oncology, the American Association for Cancer Research, and the American Society of Hematology.
Dr. Manoharan joined Alnylam in 2003. He was the former Executive Director of Medicinal Chemistry at Isis Pharmaceuticals, Inc., a leading biotechnology company focused on nucleic acid-based therapeutics where he had a12-year tenure. With a distinguished career as a world-leading nucleic acid and bioconjugate chemist, Mano is an author on over 130 publications and over 200 abstracts, as well as the inventor on over 115 issued U.S. patents. Prior to Isis Pharmaceuticals, he earned his Ph.D. in chemistry at the University of North Carolina-Chapel Hill and conducted post-doctoral work at Yale University and the University of Maryland.
Mr. Mason joined Alnylam in 2005 as Corporate Controller, and has served in roles of increasing financial and operational responsibility since that time. Prior to Alnylam, Mike was at Praecis Pharmaceuticals for five years, most recently as Corporate Controller. He began his career in financial management at KPMG LLP in 1997 where he worked with a variety of public and private audit clients. Mike received his Masters of Business Administration from Babson College and his Bachelors of Business Administration from Stetson University. He is a Certified Public Accountant.
Dr. Meyers joined Alnylam in April of 2003 as Associate Director of Research, after having served as a Senior Scientist at Millennium Pharmaceuticals (1999-2003). At Millennium Pharmaceuticals, Dr. Meyers was involved in target advancement and the identification, bioinformatic analysis, cloning and functional analysis of novel targets for small molecule drug discovery, antibody development and diagnostic purposes. At Alnylam, Dr. Meyers oversees the RLD and immunology groups and plays a key role in the development of Alnylam's RNAi therapeutic programs. Dr. Meyers holds a degree in Biochemistry from Brandeis University and a Ph.D. in Biology from MIT, and she completed her post-doctoral training at Harvard Medical School. Dr. Meyers is a member of the advisory board for the MS program in Biotechnology at Brandeis University.
Dr. Nechev joined Alnylam in 2004 and has held roles of increasing responsibility in the process development organization during that time, including the development of manufacturing processes for Alnylam pipeline programs. Prior to joining Alnylam, Lubo worked in the process development department at Transgenomic, Inc., now Agilent Technologies. Before that, he was a scientist at Ribozyme Pharmaceuticals Inc., which became Sirna Therapeutics and was acquired by Merck & Co., Inc. in 2006. Lubo received his B.S., M.S., and Ph.D. in Chemistry from the St. Kliment Ohridski University in Sofia, Bulgaria. He conducted his postdoctoral training at Vanderbilt University in Nashville
Dr. Nochur joined Alnylam in 2006 has over 19 years of experience in the areas of product development and regulatory affairs. Most recently, she held the position of Vice President, Regulatory Affairs at The Medicines Company. Prior to her four years there, she served as Director, Product Development and Regulatory Affairs for CereMedix, Inc. Sara also held senior positions at BioTrack, Inc. including Vice President, Product Development and Regulatory Affairs, and Chief Operating Officer. Prior to that she was employed by DynaGen, Inc. where she held positions of increasing responsibility, culminating in the role of Director, New Product Development. Sara received her B.S. and M.S. degrees in Microbiology from the University of Bombay in India, and her Ph.D. in Biochemical Engineering at MIT.
Dr. Placke joined Alnylam in 2013. Before joining Alnylam, Dr. Placke was President and CEO of Ricerca Biosciences, a privately held contract research company, providing integrated non-clinical drug development services to biotechnology and pharmaceutical companies. Prior to Ricerca, Dr. Placke was Vice President of Drug Safety at Wyeth Pharmaceuticals (and at Pfizer after it acquired Wyeth), where he had both operational and portfolio responsibilities for non-clinical drug safety. Before joining Wyeth he was Vice President of Research and Development of a start-up firm developing novel respiratory drug therapies. Dr. Placke has scientific and executive-level operational experience in developing a wide array of drug product modalities including small molecules, biologics, vaccines, and specialty drug products. He is formally trained in experimental pathology and toxicology, earning B.S. and M.S. degrees from The Ohio State University and his Ph.D. from the University of Connecticut. He is board certified in general toxicology, and a recent director and officer of the American Board of Toxicology.
Dr. Ruddy joined Alnylam in 2015, having previously served as Vice President of Clinical Immunology at EMD Serono. Prior to that, she spent over nine years at Merck, where she most recently led the Immunology Early Clinical Development group. She has extensive experience in translational medicine, biomarker development, program strategy, and early development evaluation of safety and proof of concept. In addition, she has led a number of project teams, including the late stage program for Merck’s inhaled asthma product, Dulera®. During part of her time at Merck, she was the clinical lead for their RNAi program. Marcie received her A.B. from Princeton University and her MD/MA from Washington University in St. Louis. She completed her medical residency at Beth Israel Hospital, Boston, and a fellowship in Pulmonary and Critical Care Medicine at Brigham and Women’s Hospital, Boston. She served on the faculty of Harvard Medical School and Massachusetts General Hospital prior to entering industry.
Dr. Tavana joined Alnylam in 2013. Before joining Alnylam, Dr. Tavana was Senior Director of Process Development and Manufacturing at Momenta Pharmaceuticals, where he was involved in the launch and commercial production of generic enoxaparin, an anticoagulant, as well as the maintenance of an uninterrupted production supply chain spanning China, Europe, and the U.S. In addition, he was involved in the development of candidate drugs for oncology and immunology indications. Prior to Momenta, Aria was at Biogen Idec, where he most recently served as Director of Quality Assurance & Quality Control. In that role he oversaw quality assurance of commercial and clinical product lines, including final drug disposition for human use. Aria joined Biogen in 1995 and held positions of increasing responsibility in process and technical development, supply chain operations, quality assurance, and quality control. Prior to joining Biogen, he was an engineer and project leader in Process Development at Novartis, where he developed chemical engineering unit operations for commercial production. Aria received his B.S. in Chemical Engineering from the University of California, Berkeley, and his Ph.D. in Chemical Engineering from the University of Arizona, Tucson.
Dr. Sepp-Lorenzino joined Alnylam in 2014. Before joining Alnylam, Dr. Sepp-Lorenzino spent 14 years at Merck & Co., having most recently served as Executive Director and Department Head, RNA Therapeutics Discovery Biology. In this role, she was responsible for identification and optimization of siRNAs and delivery vehicles, advancement of pre-clinical candidates, and development of an siRNA-conjugate platform to expand the repertoire of tissues accessible to in vivo siRNA delivery. Prior to RNAi, Laura worked in oncology drug discovery and development, having led the Cancer Research Department at Merck West Point, and having been an Assistant Lab Member at Memorial Sloan-Kettering Cancer Center. Laura received her Professional Degree in Biochemistry from the University of Buenos Aires, and her M.S. and Ph.D. in Biochemistry from New York University.