Sep 20, 2016 Press Release for Alnylam

Alnylam to Expand Global Footprint with New European Office in Maidenhead, UK

Sep 20, 2016

CAMBRIDGE, Mass. & MAIDENHEAD, United Kingdom--(BUSINESS WIRE)-- Alnylam Pharmaceuticals, Inc. (Nasdaq:ALNY), the leading RNAi therapeutics company, today announced the expansion of its global footprint with the opening of a new development and commercial hub in Maidenhead, UK. In anticipation of substantial growth across Alnylam over the next five years, the office opens with a core Clinical Development, Regulatory Affairs, and Commercial team and space for an additional 100 employees.

"Since our inception in 2002, Alnylam has pioneered new and innovative potential treatments for challenging diseases. This effort has yielded a robust clinical pipeline with 10 programmes in development across our three Strategic Therapeutic Areas or STArs," said Akshay Vaishnaw, Executive VP of R&D and Chief Medical Officer at Alnylam. "We're thrilled to be expanding our global presence in the United Kingdom and Maidenhead in particular. This important new office will play a critical role in advancing our cutting-edge investigational RNAi therapies toward regulatory approval and launch in European markets to benefit patients with life-threatening diseases as quickly as possible."

An office in Maidenhead allows Alnylam to support company growth in Europe, through its access to highly-skilled individuals, and proximity to scientific centres and regulatory agencies.

"With its strong academic and clinical research sector, as well as its universal health service and regulatory bodies constantly striving to be more streamlined and efficient, the UK has a lot to offer as a development hub for innovative medicines," added Brendan Martin, General Manager for UK & Ireland at Alnylam. "Our investment here signals a trust that the UK community will continue to treat this mission with the urgency and importance it deserves."

Alnylam's progress with its clinical programmes in the UK to date has been in large part due to the support and contributions of numerous expert collaborators at many outstanding Phase 1 units and academic sites across the UK.

The expansion is being marked with a celebration at the new Maidenhead office. Speaking at the event are the Worshipful the Mayor of the Royal Borough of Windsor and Maidenhead, Councillor Mrs. Sayonara Luxton, Steve Bates, CEO of the BioIndustry Association, and Luke Pembroke, Haemophilia patient and Youth Ambassador for the UK Haemophilia Society.

About RNAi

RNAi (RNA interference) is a revolution in biology, representing a breakthrough in understanding how genes are turned on and off in cells, and a completely new approach to drug discovery and development. Its discovery has been heralded as "a major scientific breakthrough that happens once every decade or so," and represents one of the most promising and rapidly advancing frontiers in biology and drug discovery today which was awarded the 2006 Nobel Prize for Physiology or Medicine. RNAi is a natural process of gene silencing that occurs in organisms ranging from plants to mammals. By harnessing the natural biological process of RNAi occurring in our cells, the creation of a major new class of medicines, known as RNAi therapeutics, is on the horizon. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, target the cause of diseases by potently silencing specific mRNAs, thereby preventing disease-causing proteins from being made. RNAi therapeutics have the potential to treat disease and help patients in a fundamentally new way.

About Alnylam Pharmaceuticals

Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The company is leading the translation of RNAi as a new class of innovative medicines. Alnylam's pipeline of investigational RNAi therapeutics is focused in 3 Strategic Therapeutic Areas (STArs): Genetic Medicines, with a broad pipeline of RNAi therapeutics for the treatment of rare diseases; Cardio-Metabolic Disease, with a pipeline of RNAi therapeutics toward genetically validated, liver-expressed disease targets for unmet needs in cardiovascular and metabolic diseases; and Hepatic Infectious Disease, with a pipeline of RNAi therapeutics that address the major global health challenges of hepatic infectious diseases. In early 2015, Alnylam launched its "Alnylam 2020" guidance for the advancement and commercialisation of RNAi therapeutics as a whole new class of innovative medicines. Specifically, by the end of 2020, Alnylam expects to achieve a company profile with 3 marketed products, 10 RNAi therapeutic clinical programmes - including 4 in late stages of development - across its 3 STArs. The company's demonstrated commitment to RNAi therapeutics has enabled it to form major alliances with leading companies including Ionis, Novartis, Roche, Takeda, Merck, Monsanto, The Medicines Company, and Sanofi Genzyme. In addition, Alnylam holds an equity position in Regulus Therapeutics Inc., a company focused on discovery, development, and commercialisation of microRNA therapeutics. Alnylam scientists and collaborators have published their research on RNAi therapeutics in over 200 peer-reviewed papers, including many in the world's top scientific journals such as Nature, Nature Medicine, Nature Biotechnology, Cell, New England Journal of Medicine, and The Lancet. Founded in 2002, Alnylam maintains headquarters in Cambridge, Massachusetts. For more information about Alnylam's pipeline of investigational RNAi therapeutics, please visit www.alnylam.com.

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Alnylam Pharmaceuticals, Inc.
(Investors and Media)
Christine Regan Lindenboom, 617-682-4340
or
(Investors)
Josh Brodsky, 617-551-8276

Source: Alnylam Pharmaceuticals, Inc.

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